eprintid: 115 rev_number: 10 eprint_status: archive userid: 2 importid: 0 dir: disk0/00/00/01/15 datestamp: 2021-06-01 23:55:07 lastmod: 2023-06-15 23:30:11 status_changed: 2021-06-01 23:55:07 type: article succeeds: 0 commentary: 0 metadata_visibility: show item_issues_count: 0 sword_depositor: 0 creators_name: Cañadas-Lozano, Diego creators_name: Marín-Aguilar, Fabiola creators_name: Castejón-Vega, Beatriz creators_name: Ryffel, Bernhard creators_name: Navarro-Pando, José M. creators_name: Ruiz-Cabello, Jesús creators_name: Alcocer-Gómez, Elísabet creators_name: Bullón, Pedro creators_name: Cordero, Mario D. creators_id: creators_id: creators_id: creators_id: creators_id: jose.navarro@uneatlantico.es creators_id: creators_id: creators_id: creators_id: mario.cordero@uneatlantico.es title: Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice ispublished: pub subjects: uneat_bm divisions: uneatlantico_produccion_cientifica full_text_status: none keywords: NLRP3 inflammasome; High-fat diet; Aging; Autophagy; Longevity; Obesity. abstract: Aging is the major risk factor for many metabolic chronic diseases. Several metabolic pathways suffer a progressive impairment during aging including body composition and insulin resistance which are associated to autophagy dysfunction and increased inflammation. Many of these alterations are aggravated by non-healthy lifestyle such as obesity and hypercaloric diet which have been shown to accelerate aging. Here, we show that the deleterious effect of hypercaloric diets is reverted by the NLRP3 inflammasome inhibition. NLRP3 deficiency extends mean lifespan of adult mice fed a high-fat diet. This lifespan extension is accompanied by metabolic health benefits including reduced liver steatosis and cardiac damage, improved glucose and lipid metabolism, and improved protein expression profiles of SIRT-1, mTOR, autophagic flux, and apoptosis. These findings suggest that the suppression of NLRP3 prevented many age-associated changes in metabolism impaired by the effect of hypercaloric diets. date: 2020-01 date_type: published publication: GeroScience volume: 42 number: 2 pagerange: 715-725 pages: 0 id_number: doi:10.1007/s11357-019-00151-6 refereed: TRUE issn: 2509-2715 official_url: http://doi.org/10.1007/s11357-019-00151-6 num_pieces: 0 gscholar_impact: 0 gscholar_datestamp: 0000-00-00 00:00:00 access: close language: en citation: Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica Cerrado Inglés Aging is the major risk factor for many metabolic chronic diseases. Several metabolic pathways suffer a progressive impairment during aging including body composition and insulin resistance which are associated to autophagy dysfunction and increased inflammation. Many of these alterations are aggravated by non-healthy lifestyle such as obesity and hypercaloric diet which have been shown to accelerate aging. Here, we show that the deleterious effect of hypercaloric diets is reverted by the NLRP3 inflammasome inhibition. NLRP3 deficiency extends mean lifespan of adult mice fed a high-fat diet. This lifespan extension is accompanied by metabolic health benefits including reduced liver steatosis and cardiac damage, improved glucose and lipid metabolism, and improved protein expression profiles of SIRT-1, mTOR, autophagic flux, and apoptosis. These findings suggest that the suppression of NLRP3 prevented many age-associated changes in metabolism impaired by the effect of hypercaloric diets. metadata Cañadas-Lozano, Diego; Marín-Aguilar, Fabiola; Castejón-Vega, Beatriz; Ryffel, Bernhard; Navarro-Pando, José M.; Ruiz-Cabello, Jesús; Alcocer-Gómez, Elísabet; Bullón, Pedro y Cordero, Mario D. mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, jose.navarro@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, mario.cordero@uneatlantico.es (2020) Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice. GeroScience, 42 (2). pp. 715-725. ISSN 2509-2715