TY  - JOUR
KW  - alternatives to animal testing
KW  -  food-risk assessment
KW  -  human-based research
KW  -  NAMs
KW  -  newapproachmethodologies
KW  -  novelfoodproducts
KW  -  nutritionresearch
TI  - Human?based new approach methodologies to accelerate advances in nutrition research
SN  - 2643-8429
Y1  - 2024/03//
JF  - Food Frontiers
AV  - public
A1  - Cassotta, Manuela
A1  - Cianciosi, Danila
A1  - Elexpuru Zabaleta, Maria
A1  - Elío Pascual, Iñaki
A1  - Sumalla Cano, Sandra
A1  - Giampieri, Francesca
A1  - Battino, Maurizio
EP  - 32
UR  - http://doi.org/10.1002/fft2.369
SP  - 1
N2  - Much of nutrition research has been conventionally based on the use of simplistic in vitro systems or animal models, which have been extensively employed in an effort to better understand the relationships between diet and complex diseases as well as to evaluate food safety. Although these models have undeniably contributed to increase our mechanistic understanding of basic biological processes, they do not adequately model complex human physiopathological phenomena, creating concerns about the translatability to humans. During the last decade, extraordinary advancement in stem cell culturing, three-dimensional cell cultures, sequencing technologies, and computer science has occurred, which has originated a wealth of novel human-based and more physiologically relevant tools. These tools, also known as ?new approach methodologies,? which comprise patient-derived organoids, organs-on-chip, multi-omics approach, along with computational models and analysis, represent innovative and exciting tools to forward nutrition research from a human-biology-oriented perspective. After considering some shortcomings of conventional in vitro and vivo approaches, here we describe the main novel available and emerging tools that are appropriate for designing a more human-relevant nutrition research. Our aim is to encourage discussion on the opportunity to explore innovative paths in nutrition research and to promote a paradigm-change toward a more human biology-focused approach to better understand human nutritional pathophysiology, to evaluate novel food products, and to develop more effective targeted preventive or therapeutic strategies while helping in reducing the number and replacing animals employed in nutrition research.
ID  - uneatlantico11265
ER  -