TY  - JOUR
Y1  - 2021/01//
JF  - Pharmaceutics
N2  - The application of metallic nanoparticles (materials with size at least in one dimension ranging from 1 to 100 nm) as a new therapeutic tool will improve the diagnosis and treatment of diseases. The mitochondria could be a therapeutic target to treat pathologies whose origin lies in mitochondrial dysfunctions or whose progression is dependent on mitochondrial function. We aimed to study the subcellular distribution of 2-4 nm iron nanoparticles and its effect on mitochondrial DNA (mtDNA), mitochondrial function, and autophagy in colorectal cell lines (HT-29). Results showed that when cells were exposed to ultra-small iron nanoparticles, their subcellular fate was mainly mitochondria, affecting its respiratory and glycolytic parameters, inducing the migration of the cellular state towards quiescence, and promoting and triggering the autophagic process. These effects support the potential use of nanoparticles as therapeutic agents using mitochondria as a target for cancer and other treatments for mitochondria-dependent pathologies.
IS  - 1
VL  - 13
SN  - 1999-4923
UR  - http://doi.org/10.3390/pharmaceutics13010090
TI  - Ultra-Small Iron Nanoparticles Target Mitochondria Inducing Autophagy, Acting on Mitochondrial DNA and Reducing Respiration
ID  - uneatlantico109
A1  - Rivas-García, Lorenzo
A1  - Quiles, José L.
A1  - Varela-López, Alfonso
A1  - Giampieri, Francesca
A1  - Battino, Maurizio
A1  - Bettmer, Jörg
A1  - Montes-Bayón, María
A1  - Llopis, Juan
A1  - Sánchez-González, Cristina
AV  - public
KW  - Copy number
KW  -  Metals
KW  -  Mitochondria
KW  -  MtDNA deletions
KW  -  Nanotechnology
KW  -  Respiration.
ER  -