TY  - JOUR
ID  - uneatlantico10844
AV  - public
Y1  - 2024/01//
KW  - Alzheimer?s disease; plasma biomarkers; presymptomatic stages; comorbidities; amyloid; tau protein
IS  - 3
VL  - 25
UR  - http://doi.org/10.3390/ijms25031481
A1  - Martínez-Dubarbie, Francisco
A1  - Guerra-Ruiz, Armando
A1  - López-García, Sara
A1  - Irure-Ventura, Juan
A1  - Lage, Carmen
A1  - Fernández-Matarrubia, Marta
A1  - Pozueta-Cantudo, Ana
A1  - García-Martínez, María
A1  - Corrales Pardo, Andrea
A1  - Bravo, María
A1  - Martín-Arroyo, Juan
A1  - Infante, Jon
A1  - López-Hoyos, Marcos
A1  - García-Unzueta, María Teresa
A1  - Sánchez-Juan, Pascual
A1  - Rodríguez-Rodríguez, Eloy
TI  - Influence of Physiological Variables and Comorbidities on Plasma A?40, A?42, and p-tau181 Levels in Cognitively Unimpaired Individuals
JF  - International Journal of Molecular Sciences
N2  - Plasma biomarkers for Alzheimer?s disease (AD) are a promising tool that may help in early diagnosis. However, their levels may be influenced by physiological parameters and comorbidities that should be considered before they can be used at the population level. For this purpose, we assessed the influences of different comorbidities on AD plasma markers in 208 cognitively unimpaired subjects. We analyzed both plasma and cerebrospinal fluid levels of A?40, A?42, and p-tau181 using the fully automated Lumipulse platform. The relationships between the different plasma markers and physiological variables were studied using linear regression models. The mean differences in plasma markers according to comorbidity groups were also studied. The glomerular filtration rate showed an influence on plasma A?40 and A?42 levels but not on the A?42/A?40 ratio. The amyloid ratio was significantly lower in diabetic and hypertensive subjects, and the mean p-tau181 levels were higher in hypertensive subjects. The glomerular filtration rate may have an inverse relationship on plasma A?40 and A?42 levels but not on the amyloid ratio, suggesting that the latter is a more stable marker to use in the general population. Cardiovascular risk factors might have a long-term effect on the amyloid ratio and plasma levels of p-tau181.
SN  - 1422-0067
ER  -