eprintid: 108 rev_number: 9 eprint_status: archive userid: 2 importid: 0 dir: disk0/00/00/01/08 datestamp: 2021-06-01 23:55:05 lastmod: 2022-03-03 23:55:07 status_changed: 2021-06-01 23:55:05 type: article succeeds: 0 commentary: 0 metadata_visibility: show item_issues_count: 0 sword_depositor: 0 creators_name: Rivas-García, Lorenzo creators_name: Quiles, José L. creators_name: Roma-Rodrigues, Catarina creators_name: Raposo, Luis R. creators_name: Navarro-Hortal, María D. creators_name: Romero-Márquez, Jose M. creators_name: Esteban-Muñoz, Adelaida creators_name: Varela-López, Alfonso creators_name: García, Laura Carrera creators_name: Cianciosi, Danila creators_name: Forbes Hernandez, Tamara Y. creators_name: Battino, Maurizio creators_name: Llopis, Juan creators_name: Fernandes, Alexandra R. creators_name: Baptista, Pedro V. creators_name: Sánchez-González, Cristina creators_id: creators_id: jose.quiles@uneatlantico.es creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: title: Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease ispublished: pub subjects: uneat_bm divisions: uneatlantico_produccion_cientifica full_text_status: none keywords: Antioxidants; Autophagy; Edible flowers; Flavonoids; Polyphenols; ROS. abstract: Edible flowers are being used as a new ingredient in modern gastronomy. Recently, these products have also gained interest as an important source of phenolic compounds with potential for biomedical applications. The present work studied a methanolic extract of Rosa x hybrida in which 35 individual phenolic compounds were identified. The extract has been evaluated for its antiproliferative properties in ovarian carcinoma cells. Results showed that the antiproliferative effect was associated with the induction of autophagy and apoptosis with the concomitant ROS increase probably related to mitochondria dysfunction. These antiproliferative effects might be associated with some components of the extract such as quercetin. The extract did not induce damage in healthy cells and that it was able to improve the wound healing activity. The present study also evaluated the properties of the mentioned extract in vivo in C. elegans. Tests demonstrated a lack of toxicity in the worm model. Promising results have been obtained in transgenic strains of C. elegans that produce human beta amyloid peptide, suggesting the possible utility of the extract from the point of view of Alzheimer disease. Altogether, results suggest that Rosa x hybrida extracts could be a new tool for the development of functional foods. date: 2021 date_type: published publication: Food and Chemical Toxicology volume: 149 pagerange: 112018 pages: 0 id_number: doi:10.1016/j.fct.2021.112018 refereed: TRUE issn: 0278-6915 official_url: http://doi.org/10.1016/j.fct.2021.112018 num_pieces: 0 gscholar_impact: 0 gscholar_datestamp: 0000-00-00 00:00:00 access: close language: en citation: Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica Cerrado Inglés Edible flowers are being used as a new ingredient in modern gastronomy. Recently, these products have also gained interest as an important source of phenolic compounds with potential for biomedical applications. The present work studied a methanolic extract of Rosa x hybrida in which 35 individual phenolic compounds were identified. The extract has been evaluated for its antiproliferative properties in ovarian carcinoma cells. Results showed that the antiproliferative effect was associated with the induction of autophagy and apoptosis with the concomitant ROS increase probably related to mitochondria dysfunction. These antiproliferative effects might be associated with some components of the extract such as quercetin. The extract did not induce damage in healthy cells and that it was able to improve the wound healing activity. The present study also evaluated the properties of the mentioned extract in vivo in C. elegans. Tests demonstrated a lack of toxicity in the worm model. Promising results have been obtained in transgenic strains of C. elegans that produce human beta amyloid peptide, suggesting the possible utility of the extract from the point of view of Alzheimer disease. Altogether, results suggest that Rosa x hybrida extracts could be a new tool for the development of functional foods. metadata Rivas-García, Lorenzo; Quiles, José L.; Roma-Rodrigues, Catarina; Raposo, Luis R.; Navarro-Hortal, María D.; Romero-Márquez, Jose M.; Esteban-Muñoz, Adelaida; Varela-López, Alfonso; García, Laura Carrera; Cianciosi, Danila; Forbes Hernandez, Tamara Y.; Battino, Maurizio; Llopis, Juan; Fernandes, Alexandra R.; Baptista, Pedro V. y Sánchez-González, Cristina mail SIN ESPECIFICAR, jose.quiles@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2021) Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease. Food and Chemical Toxicology, 149. p. 112018. ISSN 0278-6915