TY  - JOUR
ID  - uneatlantico108
TI  - Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease
KW  - Antioxidants; Autophagy; Edible flowers; Flavonoids; Polyphenols; ROS.
AV  - none
A1  - Rivas-García, Lorenzo
A1  - Quiles, José L.
A1  - Roma-Rodrigues, Catarina
A1  - Raposo, Luis R.
A1  - Navarro-Hortal, María D.
A1  - Romero-Márquez, Jose M.
A1  - Esteban-Muñoz, Adelaida
A1  - Varela-López, Alfonso
A1  - García, Laura Carrera
A1  - Cianciosi, Danila
A1  - Forbes Hernandez, Tamara Y.
A1  - Battino, Maurizio
A1  - Llopis, Juan
A1  - Fernandes, Alexandra R.
A1  - Baptista, Pedro V.
A1  - Sánchez-González, Cristina
JF  - Food and Chemical Toxicology
N2  - Edible flowers are being used as a new ingredient in modern gastronomy. Recently, these products have also gained interest as an important source of phenolic compounds with potential for biomedical applications. The present work studied a methanolic extract of Rosa x hybrida in which 35 individual phenolic compounds were identified. The extract has been evaluated for its antiproliferative properties in ovarian carcinoma cells. Results showed that the antiproliferative effect was associated with the induction of autophagy and apoptosis with the concomitant ROS increase probably related to mitochondria dysfunction. These antiproliferative effects might be associated with some components of the extract such as quercetin. The extract did not induce damage in healthy cells and that it was able to improve the wound healing activity. The present study also evaluated the properties of the mentioned extract in vivo in C. elegans. Tests demonstrated a lack of toxicity in the worm model. Promising results have been obtained in transgenic strains of C. elegans that produce human beta amyloid peptide, suggesting the possible utility of the extract from the point of view of Alzheimer disease. Altogether, results suggest that Rosa x hybrida extracts could be a new tool for the development of functional foods.
Y1  - 2021///
SN  - 0278-6915
UR  - http://doi.org/10.1016/j.fct.2021.112018
VL  - 149
ER  -