<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Inhibition of the NLRP3 inflammasome prevents ovarian aging"^^ . "Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age-dependent increased expression of NLRP3 in the ovary was observed in WT mice during reproductive aging. High expression of NLRP3, caspase-1, and IL-1β was also observed in granulosa cells from patients with ovarian insufficiency. Ablation of NLRP3 improved the survival and pregnancy rates and increased anti-Müllerian hormone levels and autophagy rates in ovaries. Deficiency of NLRP3 also reduced serum FSH and estradiol levels. Consistent with these results, pharmacological inhibition of NLRP3 using a direct NLRP3 inhibitor, MCC950, improved fertility in female mice to levels comparable to those of Nlrp3−/− mice. These results suggest that the NLRP3 inflammasome is implicated in the age-dependent loss of female fertility and position this inflammasome as a potential new therapeutic target for the treatment of infertility."^^ . "2021-01" . . . "7" . "1" . . "Science Advances"^^ . . . "23752548" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "María"^^ . "Mundi-Roldan"^^ . "María Mundi-Roldan"^^ . . "Elena"^^ . "Navarro-Villarán"^^ . "Elena Navarro-Villarán"^^ . . "Hal M."^^ . "Hoffman"^^ . "Hal M. Hoffman"^^ . . "Beatriz"^^ . "Castejón-Vega"^^ . "Beatriz Castejón-Vega"^^ . . "Mónica"^^ . "Condés-Hervás"^^ . "Mónica Condés-Hervás"^^ . . "Antonio J."^^ . "Pérez-Pulido"^^ . "Antonio J. Pérez-Pulido"^^ . . "Gabriel"^^ . "Mbalaviele"^^ . "Gabriel Mbalaviele"^^ . . "Elísabet"^^ . "Alcocer-Gómez"^^ . "Elísabet Alcocer-Gómez"^^ . . "Bernhard"^^ . "Ryffel"^^ . "Bernhard Ryffel"^^ . . "Chun"^^ . "Wang"^^ . "Chun Wang"^^ . . "Alberto"^^ . "Sanz"^^ . "Alberto Sanz"^^ . . "Pedro"^^ . "Bullon"^^ . "Pedro Bullon"^^ . . "José Manuel"^^ . "Navarro-Pando"^^ . "José Manuel Navarro-Pando"^^ . . "Mario D."^^ . "Cordero"^^ . "Mario D. Cordero"^^ . . "Jordi"^^ . "Muntané"^^ . "Jordi Muntané"^^ . . . . . . "Inhibition of the NLRP3 inflammasome prevents ovarian aging (Texto)"^^ . . . . . "eabc7409.full.pdf"^^ . . . "Inhibition of the NLRP3 inflammasome prevents ovarian aging (Otro)"^^ . . . . . . "indexcodes.txt"^^ . . . "Inhibition of the NLRP3 inflammasome prevents ovarian aging (Otro)"^^ . . . . . . "lightbox.jpg"^^ . . . "Inhibition of the NLRP3 inflammasome prevents ovarian aging (Otro)"^^ . . . . . . "preview.jpg"^^ . . . "Inhibition of the NLRP3 inflammasome prevents ovarian aging (Otro)"^^ . . . . . . "medium.jpg"^^ . . . "Inhibition of the NLRP3 inflammasome prevents ovarian aging (Otro)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #107 \n\nInhibition of the NLRP3 inflammasome prevents ovarian aging\n\n" . "text/html" . . . "Biomedicine"@en . "Biomedicina"@es . .