%0 Journal Article
%@ 2375-2548
%A Navarro-Pando, José Manuel
%A Alcocer-Gómez, Elísabet
%A Castejón-Vega, Beatriz
%A Navarro-Villarán, Elena
%A Condés-Hervás, Mónica
%A Mundi-Roldan, María
%A Muntané, Jordi
%A Pérez-Pulido, Antonio J.
%A Bullon, Pedro
%A Wang, Chun
%A Hoffman, Hal M.
%A Sanz, Alberto
%A Mbalaviele, Gabriel
%A Ryffel, Bernhard
%A Cordero, Mario D.
%D 2021
%F uneatlantico:107
%J Science Advances
%N 1
%P eabc7409
%T Inhibition of the NLRP3 inflammasome prevents ovarian aging
%U http://repositorio.uneatlantico.es/id/eprint/107/
%V 7
%X Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age-dependent increased expression of NLRP3 in the ovary was observed in WT mice during reproductive aging. High expression of NLRP3, caspase-1, and IL-1β was also observed in granulosa cells from patients with ovarian insufficiency. Ablation of NLRP3 improved the survival and pregnancy rates and increased anti-Müllerian hormone levels and autophagy rates in ovaries. Deficiency of NLRP3 also reduced serum FSH and estradiol levels. Consistent with these results, pharmacological inhibition of NLRP3 using a direct NLRP3 inhibitor, MCC950, improved fertility in female mice to levels comparable to those of Nlrp3−/− mice. These results suggest that the NLRP3 inflammasome is implicated in the age-dependent loss of female fertility and position this inflammasome as a potential new therapeutic target for the treatment of infertility.