@article{uneatlantico107,
           month = {Enero},
           pages = {eabc7409},
          author = {Jos{\'e} Manuel Navarro-Pando and El{\'i}sabet Alcocer-G{\'o}mez and Beatriz Castej{\'o}n-Vega and Elena Navarro-Villar{\'a}n and M{\'o}nica Cond{\'e}s-Herv{\'a}s and Mar{\'i}a Mundi-Roldan and Jordi Muntan{\'e} and Antonio J. P{\'e}rez-Pulido and Pedro Bullon and Chun Wang and Hal M. Hoffman and Alberto Sanz and Gabriel Mbalaviele and Bernhard Ryffel and Mario D. Cordero},
          volume = {7},
            year = {2021},
           title = {Inhibition of the NLRP3 inflammasome prevents ovarian aging},
         journal = {Science Advances},
          number = {1},
        abstract = {Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age-dependent increased expression of NLRP3 in the ovary was observed in WT mice during reproductive aging. High expression of NLRP3, caspase-1, and IL-1{\ensuremath{\beta}} was also observed in granulosa cells from patients with ovarian insufficiency. Ablation of NLRP3 improved the survival and pregnancy rates and increased anti-M{\"u}llerian hormone levels and autophagy rates in ovaries. Deficiency of NLRP3 also reduced serum FSH and estradiol levels. Consistent with these results, pharmacological inhibition of NLRP3 using a direct NLRP3 inhibitor, MCC950, improved fertility in female mice to levels comparable to those of Nlrp3?/? mice. These results suggest that the NLRP3 inflammasome is implicated in the age-dependent loss of female fertility and position this inflammasome as a potential new therapeutic target for the treatment of infertility.},
             url = {http://repositorio.uneatlantico.es/id/eprint/107/}
}