eprintid: 10095 rev_number: 8 eprint_status: archive userid: 2 dir: disk0/00/01/00/95 datestamp: 2023-12-14 23:30:15 lastmod: 2023-12-14 23:30:16 status_changed: 2023-12-14 23:30:15 type: article metadata_visibility: show creators_name: D’Andrea, Patrizia creators_name: Giampieri, Francesca creators_name: Battino, Maurizio creators_id: creators_id: francesca.giampieri@uneatlantico.es creators_id: maurizio.battino@uneatlantico.es title: Nutritional Modulation of Hepcidin in the Treatment of Various Anemic States ispublished: pub subjects: uneat_sn divisions: uneatlantico_produccion_cientifica full_text_status: public keywords: hepcidin; iron homeostasis; ferroptosis; anemia abstract: Twenty years after its discovery, hepcidin is still considered the main regulator of iron homeostasis in humans. The increase in hepcidin expression drastically blocks the flow of iron, which can come from one’s diet, from iron stores, and from erythrophagocytosis. Many anemic conditions are caused by non-physiologic increases in hepcidin. The sequestration of iron in the intestine and in other tissues poses worrying premises in view of discoveries about the mechanisms of ferroptosis. The nutritional treatment of these anemic states cannot ignore the nutritional modulation of hepcidin, in addition to the bioavailability of iron. This work aims to describe and summarize the few findings about the role of hepcidin in anemic diseases and ferroptosis, as well as the modulation of hepcidin levels by diet and nutrients. date: 2023-12 publication: Nutrients volume: 15 number: 24 pagerange: 5081 id_number: doi:10.3390/nu15245081 refereed: TRUE issn: 2072-6643 official_url: http://doi.org/10.3390/nu15245081 access: open language: en citation: Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Abierto Inglés Twenty years after its discovery, hepcidin is still considered the main regulator of iron homeostasis in humans. The increase in hepcidin expression drastically blocks the flow of iron, which can come from one’s diet, from iron stores, and from erythrophagocytosis. Many anemic conditions are caused by non-physiologic increases in hepcidin. The sequestration of iron in the intestine and in other tissues poses worrying premises in view of discoveries about the mechanisms of ferroptosis. The nutritional treatment of these anemic states cannot ignore the nutritional modulation of hepcidin, in addition to the bioavailability of iron. This work aims to describe and summarize the few findings about the role of hepcidin in anemic diseases and ferroptosis, as well as the modulation of hepcidin levels by diet and nutrients. metadata D’Andrea, Patrizia; Giampieri, Francesca y Battino, Maurizio mail SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2023) Nutritional Modulation of Hepcidin in the Treatment of Various Anemic States. Nutrients, 15 (24). p. 5081. ISSN 2072-6643 document_url: http://repositorio.uneatlantico.es/id/eprint/10095/1/nutrients-15-05081.pdf