TY  - JOUR
SN  - 2072-6643
Y1  - 2023/12//
IS  - 24
TI  - Nutritional Modulation of Hepcidin in the Treatment of Various Anemic States
ID  - uneatlantico10095
UR  - http://doi.org/10.3390/nu15245081
N2  - Twenty years after its discovery, hepcidin is still considered the main regulator of iron homeostasis in humans. The increase in hepcidin expression drastically blocks the flow of iron, which can come from one?s diet, from iron stores, and from erythrophagocytosis. Many anemic conditions are caused by non-physiologic increases in hepcidin. The sequestration of iron in the intestine and in other tissues poses worrying premises in view of discoveries about the mechanisms of ferroptosis. The nutritional treatment of these anemic states cannot ignore the nutritional modulation of hepcidin, in addition to the bioavailability of iron. This work aims to describe and summarize the few findings about the role of hepcidin in anemic diseases and ferroptosis, as well as the modulation of hepcidin levels by diet and nutrients.
JF  - Nutrients
VL  - 15
A1  - D?Andrea, Patrizia
A1  - Giampieri, Francesca
A1  - Battino, Maurizio
AV  - public
KW  - hepcidin; iron homeostasis; ferroptosis; anemia
ER  -